Indole
- High-purity Indole
- Extensive range of Indole
- Ideal for drug discovery applications and organic synthesis
- Fast delivery and expert support
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(1-(Methoxycarbonyl)-1H-indol-2-yl)boronic acid 95%
(1-(Phenylsulfonyl)-1H-indol-3-yl)boronic acid 97%
(1-(tert-Butoxycarbonyl)-1H-indol-4-yl)boronic acid 95%
(1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-1h-indol-2-yl)boronic acid 95%
(1-Boc-6-cyano-1H-indol-3-yl)boronic acid 95%
(1-Boc-6-cyano-1H-indol-3-yl)boronic acid pinacol ester 97%
(1-Boc-7-chloro-1H-indol-2-yl)boronic acid 97%
(1-Methyl-1H-indol-2-yl)-methanol 97%
(1-Methyl-1H-indol-2-yl)methanamine 96%
(1-Methyl-1H-indol-3-yl)methanamine 97%
(1-Methyl-1H-indol-4-yl)methanol 95%
(1-Methyl-1H-indol-5-yl)methanamine 98%
(1-Methyl-1H-indol-5-yl)methanol 95%
(1-Methyl-1H-indol-6-yl)-methylamine 90%
(1-Methyl-1H-indol-6-yl)boronic Acid Pinacol Ester 98%
(1-methyl-1H-indol-7-yl)methanamine 97%
(1-Methylindol-7-yl)methanamine HCl 97%
(1-methylindol-7-yl)methanol 97%
(1-Tosyl-1H-indol-4-yl)methanamine 95%
(1,1-Dimethylethyl)-2-borono-5-formyl-1H-Indole-1-carboxylate 95%
(1,3,3-Trimethyl-2,3-dihydro-1H-indol-5-yl)amine 95%
(1H-Indol-2-yl)-carbamic acid tert-butyl ester 95%
(1H-Indol-2-yl)methanol 97%
(1H-Indol-2-ylmethyl)amine 98%
Understanding Indole in Modern Chemistry
Explore the critical role of Indole in pharmaceutical development, medicinal chemistry research and organic chemistry.
Precision Chemistry
Advanced synthesis techniques for superior quality compounds
Great Molecules for Chemical Diversity
Our catalogue of building blocks contains a diverse range of highly functionalised and decorated compounds. The 20 years of experience in supplying cutting-edge building blocks have given us the expertise to bring you the most exciting chemical motifs, adding chemical diversity to your projects.
Our diverse catalogue is tailored for medicinal chemistry, small molecule drug discovery and organic synthesis. Our unique range of Indole adds value to any research project.
We constantly add to our catalogue; the latest additions include a range of new Indole. We continue to bring you the latest and most exciting chemical compounds.
Quality Assurance
Every Indole product in our portfolio undergoes rigorous quality control testing. Our building blocks are supplied with the highest purity standards. We provide complete analytical characterisation, including:
- ¹H and ¹³C NMR spectroscopy for structural verification
- HPLC chromatograms confirming purity levels
- Certificate of Analysis available.
- Standard purity of 95%
- Specific purity available upon request.
Diverse Applications
From oncology to neuroscience, enabling next-generation therapeutics
Indole products in our portfolio
| Indole is among the most widely studied heterocyclic scaffolds
in medicinal chemistry, present in numerous approved therapeutics and
occurring naturally in the amino acid tryptophan, a range of alkaloids, and
endogenous signalling molecules including serotonin and melatonin. Indoles
offer a planar aromatic framework with a hydrogen-bond donor at the nitrogen
and a nucleophilic C-3 position that provides a well-established point for
functionalisation, alongside productive substitution at C-2 and across the
benzene ring, allowing medicinal chemists to tune potency, selectivity, and
physicochemical properties with considerable flexibility. Indole-based drugs have outpaced other azaheterocycles in FDA approvals over the past decade, reflecting their exceptional versatility as pharmacophores across oncology, immunology, infectious disease, gastrointestinal disorders, and CNS programmes. Indoles support diverse binding modes, including hydrogen bond donation from the NH, π-stacking with aromatic residues, and hydrophobic burial of the bicyclic core within protein binding pockets, making it adaptable to a broad range of target classes including kinases, GPCRs, nuclear receptors, and complement proteases. Iptacopan (Fabhalta, Novartis) is an FDA-approved first-in-class oral complement Factor B inhibitor bearing a methoxy-methyl indole pharmacophore, approved in December 2023 as the first oral monotherapy for adults with paroxysmal nocturnal haemoglobinuria, acting proximally in the alternative complement pathway to control both intravascular and extravascular haemolysis. Osimertinib (Tagrisso, AstraZeneca), approved by the FDA in 2015 as the first-in-class third-generation EGFR tyrosine kinase inhibitor for the treatment of EGFR T790M mutation-positive metastatic non-small cell lung cancer, incorporates a pendant 1-methylindol-3-yl group attached at the C-4 position of the central pyrimidine core, confirmed in the FDA label IUPAC name, where the unfused indole makes critical contacts within the mutant EGFR kinase domain and contributes directly to the selectivity for T790M and sensitising EGFR mutations over wild-type receptor. Our range of Indoles features novel substitutions and the incorporation of synthetically tractable functional groups such as boronic acids and esters, amines, carboxylic acids, ketones, hydroxyls and halogens to enable expedient synthetic strategies. The full range can be found using the substructure feature of our Search tools. |
Frequently Asked Questions
Common questions about our Indole products.
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