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Azetidine

  • High-purity Azetidine
  • Extensive range of Azetidine
  • Ideal for drug discovery applications and organic synthesis
  • Fast delivery and expert support
Azetidine compounds are essential building blocks in pharmaceutical research. Our carefully curated selection offers diverse structures for SAR studies and lead optimization, ensuring quality and reliability for your projects.

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In Stock
Boronic acids, Azetidine AS280361-MG100

({1-Boc-azetidin-3-yl}methyl)boronic Acid Pinacol Ester 95%

CAS: 2244699-82-7
Size: 100 mg

Formula C15H28BNO4
MW 297.19
MDL MFCD27936605
Price €178.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 2.9455 HBD 0 HBA 4
In Stock
Boronic acids, Azetidine, Pyrazole AS225887-G1

(1-{1-Boc-3-(cyanomethyl)azetidin-3-yl}-1H-pyrazol-4-yl)boronic Acid Pinacol Ester 95%

CAS: 1153949-15-5
Size: 1 g

Formula C19H29BN4O4
MW 388.27
MDL MFCD28401390
Price €106.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 2.04198 HBD 0 HBA 7
In Stock
Amino Acids, Azetidine, Cyclopropane AS58320-B-MG100

(1-Azetidin-3-yl-cyclopropyl)-carbamic acid tert-butyl ester HCl 97%

CAS: 1949836-68-3
Size: 100 mg

Formula C11H21ClN2O2
MW 248.75
MDL MFCD30146446
Price €304.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 0.6867 HBD 2 HBA 4
Azetidine AS121780-MG250

(1-Benzhydryl-azetidin-3-yl)-hydrazine dihydrochloride 96%

CAS: 1235407-00-7
Size: 250 mg

Formula C16H21Cl2N3
MW 326.26
MDL MFCD07786620
Price €678.00 per 250MG
Drug-likeness properties Drug-likeness: sLogP 2.7671 HBD 2 HBA 3
Amines, Azetidine AS121760-G1

(1-Benzylazetidin-2-yl)methanamine hydrochloride 96%

CAS: 1187929-92-5
Size: 1 g

Formula C11H17ClN2
MW 212.72
MDL MFCD09997789
Price €657.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.6414 HBD 1 HBA 2
In Stock
Alcohol, Azetidine AS51969-G1

(1-Benzylazetidin-2-yl)methanol 95%

CAS: 31247-34-4
Size: 1 g

Formula C11H15NO
MW 177.25
MDL MFCD11845667
Price €247.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.2532 HBD 1 HBA 2
In Stock
Alcohol, Azetidine AS51968-G1

(1-Benzylazetidine-2,4-diyl)dimethanol 97%

CAS: 127310-66-1
Size: 1 g

Formula C12H17NO2
MW 207.27
MDL MFCD17215364
Price €86.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 0.6141 HBD 2 HBA 3
In Stock
Amines, Azetidine, Cyclopropane AS37984-G1

(1-Boc)-3-(cyclopropylamino)azetidine 95%

CAS: 1342433-96-8
Size: 1 g

Formula C11H20N2O2
MW 212.29
MDL MFCD18326835
Price €206.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.3577 HBD 1 HBA 3
In Stock
Amines, Azetidine AS96222-G1

(1-Ethylazetidin-3-yl)methanamine 97%

CAS: 1412978-07-4
Size: 1 g

Formula C6H14N2
MW 114.19
MDL MFCD21661081
Price €369.00 per 1G
Drug-likeness properties Drug-likeness: sLogP -0.1032 HBD 1 HBA 2
Alcohol, Sulfur functional groups, Azetidine AS150329-G1

(1-Methanesulfonylazetidin-2-yl)methanol 97%

CAS: 1780123-35-4
Size: 1 g

Formula C5H11NO3S
MW 165.21
MDL MFCD28652799
Price €252.00 per 1G
Drug-likeness properties Drug-likeness: sLogP -0.9874 HBD 1 HBA 3
In Stock
Alcohol, Sulfur functional groups, Azetidine AS98313-G1

(1-Methanesulfonylazetidin-3-yl)methanol 95%

CAS: 1486724-72-4
Size: 1 g

Formula C5H11NO3S
MW 165.21
MDL MFCD21661152
Price €217.00 per 1G
Drug-likeness properties Drug-likeness: sLogP -1.1299 HBD 1 HBA 3
In Stock
Amines, Azetidine AS121784-G1

(1-Methyl-azetidin-3-yl)methylamine 2HCl 98%

CAS: 1803609-11-1
Size: 1 g

Formula C5H14Cl2N2
MW 173.08
MDL MFCD28125097
Price €301.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 0.3503 HBD 1 HBA 2
In Stock
Amines, Azetidine AS57984-A-MG250

(1-Methylazetidin-2-yl)methanamine 95%

CAS: 1363382-92-6
Size: 250 mg

Formula C5H12N2
MW 100.16
MDL MFCD22397967
Price €723.00 per 250MG
Drug-likeness properties Drug-likeness: sLogP -0.3508 HBD 1 HBA 2
In Stock
Alcohol, Azetidine AS150331-MG250

(1-Methylazetidin-2-yl)methanol 97%

CAS: 1629600-48-1
Size: 250 mg

Formula C5H11NO
MW 101.14
MDL MFCD22397966
Price €293.00 per 250MG
Drug-likeness properties Drug-likeness: sLogP -0.3172 HBD 1 HBA 2
In Stock
Alcohol, Azetidine AS56813-A-G1

(1-Methylazetidin-3-yl)methanol 95%

CAS: 1499172-23-4
Size: 1 g

Formula C5H11NO
MW 101.15
MDL MFCD21661367
Price €131.00 per 1G
Drug-likeness properties Drug-likeness: sLogP -0.4597 HBD 1 HBA 2
In Stock
Alcohol, Azetidine AS56813-B-G1

(1-Methylazetidin-3-yl)methanol HCl 97%

CAS: 2174002-18-5
Size: 1 g

Formula C5H12ClNO
MW 137.15
MDL MFCD28891762
Price €142.00 per 1G
Drug-likeness properties Drug-likeness: sLogP -0.0379 HBD 1 HBA 2
In Stock
Boronic acids, Azetidine, Pyrimidine AS43849-G1

(2-(Azetidin-1-yl)pyrimidin-5-yl)boronic acid 96%

CAS: 1411643-59-8
Size: 1 g

Formula C7H10BN3O2
MW 178.98
MDL MFCD18261197
Price €307.00 per 1G
Drug-likeness properties Drug-likeness: sLogP -1.6335 HBD 2 HBA 5
In Stock
Alcohol, Azetidine AS96246-G1

(2-Methylazetidin-2-yl)methanol HCl 97%

CAS: 2227204-97-7
Size: 1 g

Formula C5H12ClNO
MW 137.61
MDL MFCD31617994
Price €926.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 0.1525 HBD 2 HBA 2
In Stock
Alcohol, Azetidine AS96414-2R3R-MG250

(2R,3R)-1-(Diphenylmethyl)-2-methylazetidin-3-ol 97%EE

CAS: 164906-65-4
Size: 250 mg

Formula C17H19NO
MW 253.35
MDL MFCD30802677
Price €449.00 per 250MG
Drug-likeness properties Drug-likeness: sLogP 2.841 HBD 1 HBA 2
In Stock
Alcohol, Azetidine AS57345-2R3R-MG100

(2R,3R)-1-Boc-3-hydroxy-2-methylazetidine 97%EE

CAS: 1638744-75-8
Size: 100 mg

Formula C9H17NO3
MW 187.24
MDL MFCD28501320
Price €199.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 0.9865 HBD 1 HBA 3
In Stock
Sulfur functional groups, Azetidine AS150410-MG100

(2R,3R)-2-Methyl-3-(methylsulfonylmethyl)azetidine HCl 97%EE

CAS: -
Size: 100 mg

Formula C6H14ClNO2S
MW 199.69
MDL MFCD34184199
Price €346.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 0.0607 HBD 1 HBA 3
In Stock
Alcohol, Azetidine AS57592-B-2R3R-MG100

(2R,3R)-2-Methylazetidin-3-ol HCl 97%EE

CAS: 2231664-90-5
Size: 100 mg

Formula C4H10ClNO
MW 123.58
MDL MFCD31705457
Price €210.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP -0.2392 HBD 2 HBA 2
Azetidine AS58599-A-2R3R-G1

(2R,3R)-3-(Boc-amino)-2-methylazetidine 97%EE

CAS: 1932396-57-0
Size: 1 g

Formula C9H18N2O2
MW 186.25
MDL MFCD30802681
Price €1,965.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 0.8714 HBD 2 HBA 3
In Stock
Azetidine AS155377-MG100

(2R,3R)-3-(Boc-amino)-2-methylazetidine HCl 97%

CAS: 2231665-45-3
Size: 100 mg

Formula C9H19ClN2O2
MW 222.71
MDL MFCD31705525
Price €339.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 1.2932 HBD 2 HBA 3

Understanding Azetidine in Modern Chemistry

Explore the critical role of Azetidine in pharmaceutical development, medicinal chemistry research and organic chemistry.

Precision Chemistry

Precision Chemistry

Advanced synthesis techniques for superior quality compounds

Great Molecules for Chemical Diversity

Our catalogue of building blocks contains a diverse range of highly functionalised and decorated compounds. The 20 years of experience in supplying cutting-edge building blocks have given us the expertise to bring you the most exciting chemical motifs, adding chemical diversity to your projects.

Our diverse catalogue is tailored for medicinal chemistry, small molecule drug discovery and organic synthesis. Our unique range of Azetidine adds value to any research project.

We constantly add to our catalogue; the latest additions include a range of new Azetidine. We continue to bring you the latest and most exciting chemical compounds.

Quality Assurance

Quality Assurance

Every Azetidine product in our portfolio undergoes rigorous quality control testing. Our building blocks are supplied with the highest purity standards. We provide complete analytical characterisation, including:

  • ¹H and ¹³C NMR spectroscopy for structural verification
  • HPLC chromatograms confirming purity levels
  • Certificate of Analysis available.
  • Standard purity of 95%
  • Specific purity available upon request.

Diverse Applications

Diverse Applications

From oncology to neuroscience, enabling next-generation therapeutics

Over 1800 Azetidine in our catalogue
Found in over 7 FDA-approved drugs
95% of compounds available from stock

Azetidine products in our portfolio

Azetidines can meaningfully improve metabolic stability and reduce lipophilicity in a lead series. The conformational restriction imposed by the strained ring can also sharpen target engagement. These properties have made the scaffold increasingly attractive across a range of therapeutic areas, including oncology, immunology, CNS disorders, cardiovascular disease, and anti-infective programs. 

One well-established example of an azetidine-containing approved drug is baricitinib (Olumiant, Eli Lilly), a selective JAK1/JAK2 inhibitor approved by the FDA in 2018 for moderately to severely active rheumatoid arthritis. 

Our range of azetidines features novel substitutions and the incorporation of synthetically tractable functional groups such as boronic acids and esters, amines, carboxylic acids, ketones, hydroxyls and halogens to enable expedient synthetic strategies. The full range can be found using the substructure feature of our Search tools.

Explore Our Complete Portfolio

Frequently Asked Questions

Common questions about our Azetidine products.

Azetidine is a four-membered saturated nitrogen-containing ring used in medicinal chemistry to improve the drug-like properties of small molecules. The ring's inherent strain restricts conformational flexibility, which can sharpen target engagement and improve selectivity. It has become increasingly attractive across oncology, immunology, CNS disorders, cardiovascular disease, and anti-infective programmes.

Incorporating an azetidine ring into a lead compound can meaningfully improve metabolic stability by replacing more metabolically vulnerable groups. The strained four-membered ring is less susceptible to certain oxidative metabolic pathways than larger saturated rings. This property, combined with its ability to reduce lipophilicity, makes azetidine a practical tool in lead optimisation when metabolic clearance is a concern.
Azetidine reduces the lipophilicity of a lead series relative to less polar ring systems. Lower lipophilicity generally correlates with improved aqueous solubility, reduced non-specific binding, and a more favourable pharmacokinetic profile. These properties are particularly valuable in programmes targeting the CNS or requiring good oral bioavailability.
Baricitinib (Olumiant, Eli Lilly) is a well-established FDA-approved drug containing an azetidine group. It is a selective JAK1 and JAK2 inhibitor approved by the FDA in 2018 for moderately to severely active rheumatoid arthritis. Baricitinib illustrates the utility of azetidine in an immunology programme where both potency and suitable pharmacokinetics are required.
Azetidine’s four-membered ring is smaller and more strained than pyrrolidine or piperidine, giving a distinct balance of reduced lipophilicity and restricted conformational freedom — useful when a larger saturated ring introduces too much lipophilicity or flexibility for a given target

Our catalogue includes derivatives bearing boronic acids and esters, amines, carboxylic acids, ketones, hydroxyls, and halogens, supporting a wide range of cross-coupling and functionalisation strategies.

Yes, our azetidine catalogue includes building blocks with enantiomeric purity confirmed by optical rotation or chiral HPLC, documented in the Certificate of Analysis.

Still have questions?

Our technical support team is here to help with any inquiries about our Azetidine products.

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