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Imidazole

  • High-purity Imidazole
  • Extensive range of Imidazole
  • Ideal for drug discovery applications and organic synthesis
  • Fast delivery and expert support
Imidazole compounds are essential building blocks in pharmaceutical research. Our carefully curated selection offers diverse structures for SAR studies and lead optimization, ensuring quality and reliability for your projects.

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In Stock
Amines, Imidazole AS217284-MG250

([1-(2-Methoxyethyl)-1H-imidazol-5-yl]methyl)amine HCl 95%

CAS: 1083300-53-1
Size: 250 mg

Formula C7H14ClN3O
MW 191.66
MDL MFCD27995756
Price €236.00 per 250MG
Drug-likeness properties Drug-likeness: sLogP 0.41 HBD 1 HBA 4
In Stock
Halides, Carboxylic acids, Sulfur functional groups, Fluorides, Imidazole AS222687-G1

([1-(3-Fluorophenyl)-1H-imidazol-2-yl]thio)acetic Acid 95%

CAS: 851879-33-9
Size: 1 g

Formula C11H9FN2O2S
MW 252.26
MDL MFCD06655283
Price €369.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 2.1881 HBD 1 HBA 4
Amines, Imidazole, Cyclopropane AS166046-MG250

({1-[(2-Ethyl-1H-imidazol-1-yl)methyl]cyclopropyl}methyl)amine 95%

CAS: 1015846-38-4
Size: 250 mg

Formula C10H17N3
MW 179.27
MDL MFCD09971231
Price €296.00 per 250MG
Drug-likeness properties Drug-likeness: sLogP 1.1844 HBD 1 HBA 3
In Stock
Amines, Fluorides, Imidazole AS192111-MG100

(1-(2-(Trifluoromethyl)benzyl)-1H-imidazol-4-yl)methanamine HCl 95%

CAS: 1439902-36-9
Size: 100 mg

Formula C12H13ClF3N3
MW 291.70
MDL MFCD25541788
Price €320.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 2.8307 HBD 1 HBA 3
In Stock
Amines, Fluorides, Imidazole AS192112-MG100

(1-(4-(Trifluoromethyl)benzyl)-1H-imidazol-4-yl)methanamine 95%

CAS: 1439899-16-7
Size: 100 mg

Formula C12H12F3N3
MW 255.24
MDL MFCD25541790
Price €320.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 2.4089 HBD 1 HBA 3
Alcohol, Imidazole AS122014-MG250

(1-Allyl-1H-imidazol-5-yl)-methanol 97%

CAS: 329378-97-4
Size: 250 mg

Formula C7H10N2O
MW 138.17
MDL MFCD04114646
Price €725.00 per 250MG
Drug-likeness properties Drug-likeness: sLogP 0.5614 HBD 1 HBA 3
In Stock
Imidazole AS74502-G1

(1-Benzyl-1H-imidazol-2-yl)-acetic acid methyl ester HCl 98%

CAS: 1176419-60-5
Size: 1 g

Formula C13H15ClN2O2
MW 266.72
MDL MFCD09970264
Price €239.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 2.0687 HBD 0 HBA 4
Amines, Imidazole AS70003-G1

(1-Benzyl-1H-imidazol-2-yl)methylamine 95%

CAS: 26163-58-6
Size: 1 g

Formula C11H13N3
MW 187.24
MDL MFCD03086167
Price €909.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.3901 HBD 1 HBA 3
Amines, Imidazole AS192087-MG100

(1-Benzyl-1H-imidazol-4-yl)methanamine HCl 95%

CAS: 1439896-60-2
Size: 100 mg

Formula C11H14ClN3
MW 223.70
MDL MFCD26097019
Price €301.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 1.8119 HBD 1 HBA 3
Imidazole AS162466-G1

(1-Benzyl-1H-imidazol-5-yl)acetonitrile HCl 95%

CAS: 1609406-86-1
Size: 1 g

Formula C12H12ClN3
MW 233.70
MDL MFCD26959602
Price €65.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 2.41928 HBD 0 HBA 3
In Stock
Amines, Imidazole AS192140-MG100

(1-Benzyl-1H-imidazol-5-yl)methanamine HCl 95%

CAS: 1439902-95-0
Size: 100 mg

Formula C11H14ClN3
MW 223.70
MDL MFCD26097039
Price €378.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 1.8119 HBD 1 HBA 3
In Stock
Amines, Imidazole AS192765-MG100

(1-Cyclobutyl-1H-imidazol-4-yl)methanamine HCl 95%

CAS: 2197062-12-5
Size: 100 mg

Formula C8H14ClN3
MW 187.67
MDL MFCD29038487
Price €320.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 1.4886 HBD 1 HBA 3
In Stock
Alcohol, Imidazole AS161106-G1

(1-Cyclohexyl-1H-imidazol-5-yl)methanol 95%

CAS: 80304-48-9
Size: 1 g

Formula C10H16N2O
MW 180.25
MDL MFCD08060036
Price €49.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.8806 HBD 1 HBA 3
In Stock
Alcohol, Imidazole, Cyclopentane AS161087-G1

(1-Cyclopentyl-1H-imidazol-5-yl)methanol 95%

CAS: 915919-86-7
Size: 1 g

Formula C9H14N2O
MW 166.22
MDL MFCD08060037
Price €49.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.4905 HBD 1 HBA 3
In Stock
Alcohol, Imidazole, Cyclopentane AS4259-G1

(1-Cyclopentyl-4-methyl-1H-imidazol-2-yl)methanol 95%

CAS: 1855907-58-2
Size: 1 g

Formula C10H16N2O
MW 180.25
MDL MFCD29910421
Price €727.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.79892 HBD 1 HBA 3
Alcohol, Imidazole, Cyclopropane AS126829-MG100

(1-Cyclopropyl-1H-imidazol-2-yl)-methanol 97%

CAS: 135207-02-2
Size: 100 mg

Formula C7H10N2O
MW 138.16
MDL MFCD19982737
Price €536.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 0.7103 HBD 1 HBA 3
Boronic acids, Imidazole, Cyclopropane AS127749-MG100

(1-Cyclopropyl-1H-imidazol-5-yl)boronic Acid Pinacol Ester 97%

CAS: 2710298-98-7
Size: 100 mg

Formula C12H19BN2O2
MW 234.10
MDL MFCD34565035
Price €1,118.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 1.5172 HBD 0 HBA 4
Alcohol, Imidazole, Cyclopropane AS162390-G1

(1-Cyclopropyl-1H-imidazol-5-yl)methanol HCl 95%

CAS: 1609401-02-6
Size: 1 g

Formula C7H11ClN2O
MW 174.63
MDL MFCD26959752
Price €65.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.1321 HBD 1 HBA 3
In Stock
Ketones, Imidazole AS166981-G1

(1-Ethyl-1H-imidazol-2-yl)(phenyl)methanone 95%

CAS: 864231-66-3
Size: 1 g

Formula C12H12N2O
MW 200.24
MDL MFCD00498180
Price €196.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 2.134 HBD 0 HBA 3
In Stock
Imidazole AS160616-G1

(1-Ethyl-1H-imidazol-2-yl)acetonitrile HCl 95%

CAS: 1609406-62-3
Size: 1 g

Formula C7H10ClN3
MW 171.63
MDL MFCD26959601
Price €49.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 1.39088 HBD 0 HBA 3
In Stock
Amines, Imidazole AS70005-G1

(1-Ethyl-1H-imidazol-2-yl)methanamine diHCl 95%

CAS: 1223542-88-8
Size: 1 g

Formula C6H13ClN3
MW 198.09
MDL MFCD08704462
Price €442.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 0.3617 HBD 1 HBA 3
In Stock
Amines, Imidazole AS70007-G1

(1-Ethyl-1H-imidazol-2-ylmethyl)-methyl-amine 95%

CAS: 920450-08-4
Size: 1 g

Formula C7H13N3
MW 139.20
MDL MFCD08060588
Price €162.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 0.6224 HBD 1 HBA 3
In Stock
Amines, Imidazole AS192762-MG100

(1-Ethyl-1H-imidazol-4-yl)methanamine HCl 95%

CAS: 2197055-75-5
Size: 100 mg

Formula C6H12ClN3
MW 161.63
MDL MFCD29038484
Price €320.00 per 100MG
Drug-likeness properties Drug-likeness: sLogP 0.7835 HBD 1 HBA 3
In Stock
Alcohol, Imidazole AS146712-G1

(1-Ethyl-1H-imidazol-5-yl)methanol 95%

CAS: 215872-62-1
Size: 1 g

Formula C6H10N2O
MW 126.15
MDL MFCD04114647
Price €65.00 per 1G
Drug-likeness properties Drug-likeness: sLogP 0.3953 HBD 1 HBA 3

Understanding Imidazole in Modern Chemistry

Explore the critical role of Imidazole in pharmaceutical development, medicinal chemistry research and organic chemistry.

Precision Chemistry

Precision Chemistry

Advanced synthesis techniques for superior quality compounds

Great Molecules for Chemical Diversity

Our catalogue of building blocks contains a diverse range of highly functionalised and decorated compounds. The 20 years of experience in supplying cutting-edge building blocks have given us the expertise to bring you the most exciting chemical motifs, adding chemical diversity to your projects.

Our diverse catalogue is tailored for medicinal chemistry, small molecule drug discovery and organic synthesis. Our unique range of Imidazole adds value to any research project.

We constantly add to our catalogue; the latest additions include a range of new Imidazole. We continue to bring you the latest and most exciting chemical compounds.

Quality Assurance

Quality Assurance

Every Imidazole product in our portfolio undergoes rigorous quality control testing. Our building blocks are supplied with the highest purity standards. We provide complete analytical characterisation, including:

  • ¹H and ¹³C NMR spectroscopy for structural verification
  • HPLC chromatograms confirming purity levels
  • Certificate of Analysis available.
  • Standard purity of 95%
  • Specific purity available upon request.

Diverse Applications

Diverse Applications

From oncology to neuroscience, enabling next-generation therapeutics

Over 1800 Imidazole in our catalogue
Found in over 35 FDA-approved drugs
95% of compounds available from stock

Imidazole products in our portfolio

Imidazole is among the most widely used nitrogen heterocycles in medicinal chemistry, present in a broad range of approved therapeutics and in many biologically active natural products including histamine, histidine, and the purine bases of nucleic acids. The ring bears two nitrogen atoms with distinct electronic character: one pyridine-like nitrogen that acts as a hydrogen bond acceptor and one pyrrole-like nitrogen that acts as a hydrogen bond donor. This combination allows imidazole-containing compounds to engage in a diverse range of non-covalent interactions with biological targets, including hydrogen bonding, van der Waals contacts, and hydrophobic interactions with enzyme active sites and receptor binding pockets. The imidazole nitrogen can also coordinate directly to metal centres, which has been exploited extensively in the design of enzyme inhibitors that target haem-containing proteins.

The scaffold appears across multiple therapeutic areas including anti-infective, antifungal, antiprotozoal, anticancer, and cardiovascular programmes, reflecting both its versatility as a pharmacophore and its favourable physicochemical properties. Metronidazole (Flagyl, Pfizer) is an FDA-approved nitroimidazole antimicrobial that exploits intracellular reduction of its nitro group to generate reactive intermediates that interact with DNA, producing strand breaks and leading to cell death in anaerobic bacteria and protozoa. Ketoconazole (Nizoral, Janssen) is an FDA-approved synthetic imidazole antifungal, approved in 1981, whose mechanism relies on inhibition of cytochrome P450-dependent sterol 14-alpha-demethylase, disrupting fungal membrane integrity.   

Our range of Imidazoles features novel substitutions and the incorporation of synthetically tractable functional groups such as boronic acids and esters, amines, carboxylic acids, ketones, hydroxyls and halogens to enable expedient synthetic strategies. The full range can be found using the substructure feature of our Search tools.

Explore Our Complete Portfolio

Frequently Asked Questions

Common questions about our Imidazole products.

Imidazole is a five-membered nitrogen heterocycle widely used in medicinal chemistry and present in many approved therapeutics, as well as in natural products such as histamine, histidine, and the purine bases of nucleic acids. The ring contains two nitrogen atoms with different electronic characters, allowing it to act as both a hydrogen bond donor and acceptor. This dual functionality enables imidazole-containing compounds to engage productively with a broad range of enzyme active sites and receptor binding pockets.

The two nitrogen atoms in imidazole have distinct electronic characters. One is pyridine-like and acts as a hydrogen bond acceptor, while the other is pyrrole-like and acts as a hydrogen bond donor. This combination allows imidazole to participate in diverse non-covalent interactions including hydrogen bonding, van der Waals contacts, and hydrophobic interactions, giving it broad utility across many target classes.
The nitrogen atoms of imidazole can coordinate directly to metal centres, a property exploited extensively in the design of inhibitors targeting haem-containing proteins. Ketoconazole, for example, uses its imidazole nitrogen to coordinate with the iron of cytochrome P450-dependent sterol 14-alpha-demethylase in fungi, blocking a key step in fungal membrane synthesis and disrupting membrane integrity.
Imidazole-containing drugs span multiple therapeutic areas including anti-infective, antifungal, antiprotozoal, anticancer, and cardiovascular programmes. This breadth reflects both the scaffold's pharmacological versatility and its generally favourable physicochemical properties. The ability to engage diverse target classes through varied non-covalent interactions underlies its appearance across so many disease areas.
Metronidazole (Flagyl) is a nitroimidazole antimicrobial in which the nitro group attached to the imidazole ring is reduced intracellularly in anaerobic organisms. This reduction generates reactive intermediates that interact with DNA, causing strand breaks and leading to cell death. The selectivity for anaerobic bacteria and protozoa arises because these organisms possess the low-redox-potential electron transport proteins required for nitro group reduction.
Ketoconazole (Nizoral) is a synthetic imidazole antifungal first approved in 1981 that works by inhibiting cytochrome P450-dependent sterol 14-alpha-demethylase in fungi. Blocking this enzyme disrupts the biosynthesis of ergosterol, a key component of fungal cell membranes, compromising membrane integrity. The imidazole ring coordinates to the haem iron of the enzyme, providing the basis for its selective inhibitory activity.
Imidazole building blocks are available with a range of functional groups including boronic acids and esters, amines, carboxylic acids, ketones, hydroxyls, and halogens. These substituents provide diverse handles for cross-coupling reactions, nucleophilic substitutions, and other synthetic transformations, supporting efficient structure-activity relationship exploration across a variety of lead optimisation programmes.

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