Access our catalogue of 140,000+ high-quality heterocyclic building blocks and complex scaffolds. Trusted by medicinal chemists worldwide for over 20 years.
Rigorous QC >95% Purity
Global delivery available
PhD-level technical assistance
Expert synthesis services for complex molecules and scale-up production tailored to your needs.
As a leading supplier of chemicals and building blocks for pharmaceutical research and synthetic chemistry, we provide access to over 140,000 high-quality compounds. Our comprehensive product portfolio is based on our 20 years experience providing innovative and cutting-edge building blocks with the highest quality. Our catalogue includes heterocycles, fluorinated compounds, spirocycles, cycloalkyls, boronic acids, amino acids, PEG linkers, alkynes, azides and much more – all available for fast delivery to support your research projects.
Our chemical building blocks are used by leading pharmaceutical companies, biotechnology firms, and academic research institutions worldwide. We pride ourselves on our high-quality products and customer service. Every product is delivered with the highest quality standards for your research projects.
We offer an extensive range of over 140,000 building blocks and chemical reagents including heterocycles, amino acids, boronic acids, PEG linkers, fluorinated compounds, spiro compounds, cycloalkyls, alkynes, azides, bicyclic rings, catalysts and many more specialised compounds for, organic chemistry, pharmaceutical research and drug discovery.
It is our top priority to provide high purity products to our customers. Our products are supplied with a standard purity of 95%, many with >98% or >99%. Each batch is verified through state-of-the-art analytical methods (NMR, HPLC, LC-MS) and documented with a Certificate of Analysis (CoA). Specific purity available upon request.
95% of our catalogue products are in stock, with delivery worldwide within 5 working days. Our experienced chemists ensure that for custom synthesis projects, typical delivery times range from 2-8 weeks with superior success rates.
Yes, we provide professional custom synthesis services for tailored chemical compounds. Our experienced team of chemists can synthesise complex molecules from milligram to kilogram quantities. We specialise in organic synthesis, amino synthesis, heterocyclic chemistry, fluorine chemistry, boronic acid derivatives, and chiral synthesis.
Our product purity is validated by our QC department, with a Certificate of Analysis (CoA) available for all purchased material. Purity is determined by NMR spectra (¹H-NMR, ¹³C-NMR), HPLC chromatograms, mass spectrometry (MS/LC-MS) data. The enantiomeric excess of chiral compounds is determined by optical rotation or chiral HPLC.
Absolutely. Our service supports projects from process development to pilot production. We can produce compounds in quantities ranging from milligrams for initial screening to kilograms for preclinical and clinical studies. We can support you through the drug discovery process at all scales. We optimize synthetic routes for maximum yield, minimum cost, and improved sustainability.
We deliver building blocks and reagents worldwide with complete documentation for international shipping from our offices in Germany and the UK. Our experienced logistics department handles all regulatory requirements, dangerous goods documentation, and customs paperwork. We have local inventory in Germany and the UK for faster delivery.
We offer an advanced structure search tool powered by Marvin JS technology that allows you to search by molecular structure, substructure, and similarity. You can draw your target structure directly in the browser and find exact matches, similar compounds, or building blocks containing specific substructures. You can also search our catalogue using compound ID, name, CAS and SMILES code.
Yes, our catalogue supports CAS number based searching. Our search tools allow you to search using:
We also offer structure search. Our search tools offer Substructure search, Exact structure and Similarity search. This allows you to find the product you want as quickly and easily as possible. Our quick and easy-to-use search tools help you save time when looking for chemicals. The similarity and structure search helps you easily find great alternatives if we do not have the material you are looking for.
Yes, our chemical building blocks are specifically designed for pharmaceutical research and drug discovery. They are used by all big pharmaceutical companies, biotechnology firms, and academic research institutions worldwide for applications including drug discovery, lead optimisation, fragment-based drug design, and chemical biology.
Yes, we work under strict confidential non-disclosure agreements (NDAs) for all custom synthesis projects. We protect your intellectual property throughout the entire project and maintain complete confidentiality regarding your compound structures, research goals, and project details.
Our products are used in diverse research areas including drug discovery and lead optimization, fragment-based drug design (FBDD), chemical biology and probe development, agrochemical research, materials science, peptide and protein conjugation, bioconjugation, click chemistry, and medicinal chemistry research across various therapeutic areas.
Yes, the catalogue includes PEG linkers, alkyl linkers, and functional building blocks commonly used in PROTAC design, including amine and carboxylic acid termini for coupling to both the target ligand and the E3 ligase binder. The linker catalogue alone contains over 400 PEG linker products at high purity. In addition to our linkers, we also offer CRBN ligands and VHL ligands. We have established a robust library of pre-formed E3-ligand linker intermediates. This resource enables the efficient synthesis of a wide array of diverse PROTAC candidates, facilitating their rapid evaluation and optimisation for targeted protein degradation applications.
For bespoke PROTAC linker synthesis or custom bifunctional molecules, the custom synthesis team can be contacted using our contact tools.
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The team at the EFMC International Symposium on Medicinal Chemistry is enjoying a fantastic event so far! We'd love to put faces to names, hear what's slowing down your current campaigns, and talk through where our catalogue might actually help. Check out the video below to see where to find us, and if you're in Basel this week, swing by.
Since Prontosil’s introduction in the 1930s, the sulfonamide functional group has evolved far beyond its origins as an antibacterial pharmacophore. Its appeal comes from a combination of properties that chemists still rely on today: the sulfonyl group is a strong hydrogen-bond acceptor, the N–H can act as a donor, and the tetrahedral geometry at sulfur provides a distinct vector for introducing three-dimensionality into a molecule. Sulfonamides are also often metabolically robust, which may help explain why they continue to reappear in optimisation campaigns even as newer bioisosteres such as sulfonimidamides gain attention. That longevity is reflected across FDA-approved medicines. Estimates of exactly how many approved drugs contain a sulfonamide range from around ninety to well over a hundred, spanning a remarkably broad range of therapeutic areas, including antibacterial, diuretic, anti-inflammatory, antihypertensive, antiviral, and oncology indications. Celecoxib uses a primary sulfonamide to achieve its characteristic COX-2 selectivity, while furosemide contains a sulfonamide group that contributes to its binding interactions within the Na-K-2Cl cotransporter in the loop of Henle. More recently, revumenib, approved by the FDA in November 2024 as the first menin inhibitor for KMT2A-rearranged acute leukaemia, incorporates an ethanesulfonamide group that makes key hydrogen-bonding interactions within the menin binding pocket. That approval was later expanded in 2025 to include NPM1-mutant AML, highlighting how the motif continues to appear even in modern programmes targeting protein-protein interactions. Sulfonamides remain one of the clearest examples of a functional group that has continued to find new roles across successive generations of drug discovery. Explore our range of building blocks using the advanced search tools at https://lnkd.in/eVbfw6Ua. Further reading: 1\) Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues https://lnkd.in/e2\_4v9Gg 2\) Sulfonamides as a Promising Scaffold in Drug Discovery: An Insightful Review on FDA-Approved Molecules, Synthesis Strategy, Medical Indication, and Their Binding Mode https://lnkd.in/equTiknx 3\) Sulfur- and phosphorus-containing FDA approved drugs in the last five years \(2020-2024\): A journey among small molecules https://lnkd.in/eJw3jGap
Our building blocks are supplied with the highest purity standards. With a standard purity of 95%, many with >98% or >99%. Each batch is verified through state-of-the-art analytical methods (NMR, HPLC, LC-MS) and documented with a Certificate of Analysis (CoA). Specific purity available upon request.
Over 95% of our products are available in stock and can be shipped via express delivery. Quick and easy EU shipping is available from our German office. For special requirements, we also offer express synthesis and customized production timelines.
We deliver chemical molecules and reagents worldwide with complete documentation for international shipping. Our experienced logistics department handles all regulatory requirements and shipping documentation.
Our diverse catalogue is highly tailored for medicinal chemistry, small molecule drug discovery and organic synthesis. Our unique range of building blocks adds value to any research project.
Our diverse catalogue includes a wide range of aromatic, sp3, chiral, bicyclic, spirocyclic and highly functionalised building blocks. We have the molecules you need to make your project progress.
Our product range is continuously expanded based on current trends in medicinal chemistry and drug discovery. We monitor leading scientific publications and add new compounds daily that are relevant for drug discovery, fragment-based development, and chemical biology research.
Use our powerful Marvin JS tool to search by molecular structure, substructure, and similarity
Explore our extensive catalogue of high-purity compounds
Beyond our extensive catalog, we offer reliable custom synthesis services for tailored chemical compounds. Our experienced team of chemists can synthesise complex molecules from milligram to kilogram quantities.
Organic Synthesis – from simple building blocks to complex multi-step syntheses Amino acid Synthesis – modified amino acids and decorated unnatural amino acids Heterocyclic Chemistry – pyridines, pyrimidines, oxazoles, thiazoles, piperazines, indoles and more Fluorine Chemistry - selective fluorination, trifluoromethylation and other fluorine substitution Boronic Acid Derivatives – pinacol esters, trifluoroborate salts, MIDA boronates Chiral Synthesis – enantiomerically pure compounds, asymmetric catalysis
Our scale-up service supports you from process development to pilot production. We optimise synthetic routes for maximum yield, minimum cost, and improved sustainability. Whether you need 100 grams for preclinical studies or several kilograms – we have the capacity and expertise.
All custom synthesis projects are delivered with complete process documentation, analytical data, and regulatory support. We work under confidential non-disclosure agreements (NDAs) and protect your intellectual property throughout the entire project.
With over 20 years of experience in the chemical industry and pharmaceutical research, we have established ourselves as a reliable partner for scientists and researchers worldwide. Our team of experienced chemists possesses comprehensive expertise in organic synthesis, medicinal chemistry, and process development.
Rigorous QC verified through state-of-the-art analytical methods
Delivery to over 80 countries, local inventory in Germany and the UK
Our chemical building blocks and specialty chemicals are used in diverse research areas:
We understand the specific requirements of pharmaceutical research and development and offer not only high-quality products but also comprehensive technical support. Our scientific team is available to assist you with product selection, synthesis planning, and analytical methods.
All products mentioned are intended for research and development purposes only and are not for human use or diagnostic applications.
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