Fluorinated functionalisation and sp3-hybridised carbon atoms are two of the most exciting areas being explored in medicinal chemistry today. Research has shown that three-dimensional ring structures such as cyclopropane and cyclobutane offer the possibility of increased solubility and the opportunity of accessing biological targets with more globular shapes. Furthermore with a proven track record of successful progression through clinical testing, as demonstrated in the leukotriene C4 synthase inhibitors - WO2016177845 (AstraZeneca) and the orexin receptor antagonists - US20120095031 (EIsai) it is no surprise that sp3 hybridised cycloalkyls are increasing in popularity. The presence of fluorine has also been well documented, particularly in influencing the metabolic stability and physico-chemical properties of compounds. Whilst most studies have focussed on the lowering of pKa values on the basic nitrogen in heterocyclic, an increased number are looking into fluorinated cycloalkyls as an alternative.
Fluorinated functionalisation and sp3-hybridised carbon atoms are two of the most exciting areas being explored in medicinal chemistry today. Research has shown that three-dimensional ring... read more »
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Fluorinated functionalisation and sp3-hybridised carbon atoms are two of the most exciting areas being explored in medicinal chemistry today. Research has shown that three-dimensional ring structures such as cyclopropane and cyclobutane offer the possibility of increased solubility and the opportunity of accessing biological targets with more globular shapes. Furthermore with a proven track record of successful progression through clinical testing, as demonstrated in the leukotriene C4 synthase inhibitors - WO2016177845 (AstraZeneca) and the orexin receptor antagonists - US20120095031 (EIsai) it is no surprise that sp3 hybridised cycloalkyls are increasing in popularity. The presence of fluorine has also been well documented, particularly in influencing the metabolic stability and physico-chemical properties of compounds. Whilst most studies have focussed on the lowering of pKa values on the basic nitrogen in heterocyclic, an increased number are looking into fluorinated cycloalkyls as an alternative.
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AS51105-G1 3,3-Difluorocyclobutane-1-methanol 97+%
Catalog # AS51105 Formula: C5H8F2O Mass: 122.11 C.A.S. / related C.A.S: [681128-39-2] / [] MDL: MFCD11877861 Appearance: clear liquid Colour: colorless - slightly colored Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate...
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AS51757-B-G1 4,4-Difluorocyclohexan-1-amine HCl 97+%
Catalog # AS51757-B Formula: C6H12ClF2N Mass: 171.62 C.A.S. / related C.A.S: [675112-70-6] / [] MDL: MFCD06246881 Appearance: solid Colour: white to yellow Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa:...
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AS51664-MG100 2-Amino-2-(3,3-difluorocyclobutyl)acetonitrile...
Catalog # AS51664 Formula: C6H9ClF2N2 Mass: 182.60 C.A.S. / related C.A.S: [1215166-79-2] / [] MDL: MFCD16039585 Appearance: powder Colour: off white Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: 5,911...
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AS51692-MG250 1-(Boc-amino)-2,2-difluorocyclopropane-1-carbox...
Catalog # AS51692 Formula: C9H13F2NO4 Mass: 237.20 C.A.S. / related C.A.S: [796882-45-6] / [] MDL: MFCD16039589 Appearance: powder Colour: off white Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: 0,85 pKa: 2,603...
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AS15329-G1 3,3-Difluorocyclobutane-1-carboxylic acid 97+%
Catalog # AS15329 Formula: C5H6F2O2 Mass: 136.10 C.A.S. / related C.A.S: [107496-54-8] / [] MDL: MFCD08705857 Appearance: crystal -powder Colour: white - slightly pale yellow Hazardous Classification: Corrosive Storage Temp: 2-7°C...
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AS15100-MG250 3,3-Difluorocyclobutane-1-carbonitrile 97+%
Catalog # AS15100 Formula: C5H5F2N Mass: 117.10 C.A.S. / related C.A.S: [86770-80-1] / [] MDL: MFCD10001482 Appearance: powder Colour: off white Hazardous Classification: Corrosive Storage Temp: -20°C Freezer logP: 0,87 pKa: Tariff Code:...
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AS22402-G1 4-(Trifluoromethyl)cyclohexanol 97%
Catalog # AS22402 Formula: C7H11F3O Mass: 168.16 C.A.S. / related C.A.S: [30129-18-1] / [] MDL: MFCD00102144 Appearance: clear liquid Colour: colorless - slightly colored Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate...
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AS21401-G25 4-(Trifluoromethyl)cyclohexanecarboxylic acid...
Catalog # AS21401 Formula: C8H11F3O2 Mass: 196.17 C.A.S. / related C.A.S: [95233-30-0] / [] MDL: MFCD00220049 Appearance: powder Colour: off white Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: 2,36 pKa: 4,577...
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AS51653-MG100 1,1-Difluoro-5-azaspiro[2.4]heptane HCl 97+%
Catalog # AS51653 Formula: C6H10ClF2N Mass: 169.14 C.A.S. / related C.A.S: [1215071-12-7] / [] MDL: MFCD16039586 Appearance: liquid Colour: tan Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: 8,542 Tariff...
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AS51654-C-MG100 6,6-Difluoro-3-azabicyclo[3.1.0]hexane...
Catalog # AS51654-C Formula: C5H8F2NCl Mass: 155.58 C.A.S. / related C.A.S: [1630906-58-9] / [] MDL: MFCD28166289 Appearance: powder Colour: off white Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: -0.926,...
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