Fluorinated functionalisation and sp3-hybridised carbon atoms are two of the most exciting areas being explored in medicinal chemistry today. Research has shown that three-dimensional ring structures such as cyclopropane and cyclobutane offer the possibility of increased solubility and the opportunity of accessing biological targets with more globular shapes. Furthermore with a proven track record of successful progression through clinical testing, as demonstrated in the leukotriene C4 synthase inhibitors - WO2016177845 (AstraZeneca) and the orexin receptor antagonists - US20120095031 (EIsai) it is no surprise that sp3 hybridised cycloalkyls are increasing in popularity. The presence of fluorine has also been well documented, particularly in influencing the metabolic stability and physico-chemical properties of compounds. Whilst most studies have focussed on the lowering of pKa values on the basic nitrogen in heterocyclic, an increased number are looking into fluorinated cycloalkyls as an alternative.
Fluorinated functionalisation and sp3-hybridised carbon atoms are two of the most exciting areas being explored in medicinal chemistry today. Research has shown that three-dimensional ring... read more »
Close window
Fluorinated functionalisation and sp3-hybridised carbon atoms are two of the most exciting areas being explored in medicinal chemistry today. Research has shown that three-dimensional ring structures such as cyclopropane and cyclobutane offer the possibility of increased solubility and the opportunity of accessing biological targets with more globular shapes. Furthermore with a proven track record of successful progression through clinical testing, as demonstrated in the leukotriene C4 synthase inhibitors - WO2016177845 (AstraZeneca) and the orexin receptor antagonists - US20120095031 (EIsai) it is no surprise that sp3 hybridised cycloalkyls are increasing in popularity. The presence of fluorine has also been well documented, particularly in influencing the metabolic stability and physico-chemical properties of compounds. Whilst most studies have focussed on the lowering of pKa values on the basic nitrogen in heterocyclic, an increased number are looking into fluorinated cycloalkyls as an alternative.
Close filters
 
  •  
from to
1 From 27
No results were found for the filter!
AS102467-S-MG250 (S)-tert-Butoxycarbonylamino-(4,4-difluoro-cycl...
Catalog # AS102467-S Formula: C13H21F2NO4 Mass: 293.30 C.A.S. / related C.A.S: [394735-65-0] / [] MDL: MFCD28501990 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 695.00 € *
3,3-Difluorocyclohexanamine 95+% 3,3-Difluorocyclohexanamine 95+%
Catalog # AS33951-A Formula: C6H11F2N Mass: 135.15 C.A.S. / related C.A.S: [921753-34-6] / [] MDL: MFCD12755815 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code: 0...
From 645.00 € *
AS97072-MG250 1-Amino-4,4-difluorocyclohexane-1-carboxylic...
Catalog # AS97072 Formula: C7H11F2NO2 Mass: 179.16 C.A.S. / related C.A.S: [1240529-10-5] / [] MDL: MFCD16547765 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 210.00 € *
AS97036-MG100 [(1S)-2,2-Difluorocyclopropyl]methanol 95+%
Catalog # AS97036 Formula: C4H6F2O Mass: 108.09 C.A.S. / related C.A.S: [1887036-19-2] / [] MDL: MFCD31695798 Appearance: liquid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 363.00 € *
AS97039-MG100 3-(Difluoromethyl)cyclobutan-1-one 95+%
Catalog # AS97039 Formula: C5H6F2O Mass: 120.10 C.A.S. / related C.A.S: [1461713-56-3] / [] MDL: MFCD25371848 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 256.00 € *
AS97043-MG100 3-Fluoro-1-methylcyclobutan-1-amine...
Catalog # AS97043 Formula: C5H11ClFN Mass: 139.60 C.A.S. / related C.A.S: [1781122-54-0] / [] MDL: MFCD31618008 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 214.00 € *
AS97046-G1 2-(3-Fluorocyclobutyl)acetic acid 95+%
Catalog # AS97046 Formula: C6H9FO2 Mass: 132.13 C.A.S. / related C.A.S: [1782410-66-5] / [] MDL: MFCD28539037 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
1,580.00 € *
AS97001-MG100 trans-2-(Trifluoromethyl)cyclopropane-1-carboxy...
Catalog # AS97001 Formula: C5H5F3O2 Mass: 154.09 C.A.S. / related C.A.S: [78376-99-5] / [] MDL: MFCD18027181 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 240.00 € *
AS97008-MG100 Methyl...
Catalog # AS97008 Formula: C6H9FO3 Mass: 148.13 C.A.S. / related C.A.S: [2168082-49-1] / [] MDL: MFCD31695855 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 269.00 € *
AS96991-MG100 3-Fluorobicyclo[1.1.1]pentan-1-amine...
Catalog # AS96991 Formula: C5H9ClFN Mass: 137.58 C.A.S. / related C.A.S: [1826900-79-1] / [] MDL: MFCD28963742 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 285.00 € *
AS96945-MG100 (3-Fluorocyclobutyl)methanol 95+%
Catalog # AS96945 Formula: C5H9FO Mass: 104.12 C.A.S. / related C.A.S: [1260654-20-3] / [] MDL: MFCD15527038 Appearance: liquid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 159.00 € *
AS59889-B-1R2R-MG100 (1R,2R)-2-Fluorocyclopentan-1-amine HCl 95+%
Catalog # AS59889-B-1R2R Formula: C5H11ClFN Mass: 139.60 C.A.S. / related C.A.S: [2227197-40-0] / [] MDL: Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code: 29213099...
From 359.00 € *
1 From 27
Viewed