Bicyclo[2.2.2]octane

As previously introduced, Bicyclo[2.2.2]octane is a 3D isosteres of the 2D phenyl ring, together with Bicyclo[1.1.1]pentane. Due to the presence of all sp3 carbons, Bicyclo[2.2.2]octanes can offer a number advantages over the traditional phenyl ring. The 3D structure can improve the binding site selectivity and efficiency, thus reducing toxicity and enhancing the potency of the drug. Furthermore, the lack of aromaticity could result in higher solubility. It is, however, important to keep into consideration the larger ring and increased lipophilicity of Bicyclo[2.2.2]octanes when planning to use these building blocks as phenyl isosteres.

As previously introduced, Bicyclo[2.2.2]octane is a 3D isosteres of the 2D phenyl ring, together with Bicyclo[1.1.1]pentane. Due to the presence of all sp3 carbons, Bicyclo[2.2.2]octanes can... read more »
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Bicyclo[2.2.2]octane

As previously introduced, Bicyclo[2.2.2]octane is a 3D isosteres of the 2D phenyl ring, together with Bicyclo[1.1.1]pentane. Due to the presence of all sp3 carbons, Bicyclo[2.2.2]octanes can offer a number advantages over the traditional phenyl ring. The 3D structure can improve the binding site selectivity and efficiency, thus reducing toxicity and enhancing the potency of the drug. Furthermore, the lack of aromaticity could result in higher solubility. It is, however, important to keep into consideration the larger ring and increased lipophilicity of Bicyclo[2.2.2]octanes when planning to use these building blocks as phenyl isosteres.

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AS59600-G1 Methyl...
Catalog # AS59600 Formula: C15H25NO4 Mass: 283.36 C.A.S. / related C.A.S: [943845-74-7] / [] MDL: MFCD22577782 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 155.00 € *
AS45702-MG250 Bicyclo[2.2.2]octane-1,4-diyldimethanol 98%
Catalog # AS45702 Formula: C10H18O2 Mass: 170.25 C.A.S. / related C.A.S: [826-45-9] / [] MDL: MFCD23135544 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code: 29420000...
From 240.00 € *
AS45287-MG250 4-(Hydroxymethyl)bicyclo[2.2.2]octane-1-carboxy...
Catalog # AS45287 Formula: C10H16O3 Mass: 184.23 C.A.S. / related C.A.S: [828-52-4] / [] MDL: MFCD20640208 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 228.00 € *
AS59332-G1 1,4-Dimethyl...
Catalog # AS59332 Formula: C12H18O4 Mass: 226.27 C.A.S. / related C.A.S: [1459-96-7] / [] MDL: MFCD01312167 Appearance: solid Colour: white to yellow Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff...
From 139.00 € *
AS58604-MG250 4-(Boc-amino)-1-ethenyl-2-oxabicyclo[2.2.2]octa...
Catalog # AS58604 Formula: C14H23NO3 Mass: 253.34 C.A.S. / related C.A.S: [1416374-98-5] / [] MDL: MFCD23099503 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 372.00 € *
AS58618-MG250 4-Hydroxybicyclo[2.2.2]octane-1-carboxylic acid...
Catalog # AS58618 Formula: C9H14O3 Mass: 170.21 C.A.S. / related C.A.S: [1127-13-5] / [] MDL: MFCD00102273 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 320.00 € *
AS58560-MG250 1-Ethenyl-2-oxabicyclo[2.2.2]octane-4-carboxyli...
Catalog # AS58560 Formula: C10H14O3 Mass: 182.22 C.A.S. / related C.A.S: [340023-04-3] / [] MDL: MFCD20658989 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
1,280.00 € *
AS58430-MG100 4-{[(Benzyloxy)carbonyl]amino}bicyclo[2.2.2]oct...
Catalog # AS58430 Formula: C17H21NO4 Mass: 303.35 C.A.S. / related C.A.S: [444344-91-6] / [] MDL: MFCD22741481 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 195.00 € *
AS58093-MG100 1-(Boc-amino)-4-aminobicyclo[2.2.2]octane 97+%
Catalog # AS58093 Formula: C13H24N2O2 Mass: 240.35 C.A.S. / related C.A.S: [1630906-54-5] / [] MDL: MFCD27987308 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 317.00 € *
AS90915-G1 Methyl...
Catalog # AS90915 Formula: C10H15BrO2 Mass: 247.13 C.A.S. / related C.A.S: [23062-51-3] / [] MDL: MFCD22577785 Appearance: solid Colour: white to yellow Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff...
768.00 € *
AS90642-G1 Methyl...
Catalog # AS90642 Formula: C18H23NO4 Mass: 317.38 C.A.S. / related C.A.S: [862501-91-5] / [] MDL: MFCD14706267 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 210.00 € *
AS57289-MG250 Bicyclo[2.2.2]octane-1,4-dicarboxylic acid 97+%
Catalog # AS57289 Formula: C10H14O4 Mass: 198.22 C.A.S. / related C.A.S: [711-02-4] / [] MDL: MFCD00498000 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: 1,75 pKa: 4.617, 4.617...
From 125.00 € *
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