Bicyclo[2.2.2]octane

As previously introduced, Bicyclo[2.2.2]octane is a 3D isosteres of the 2D phenyl ring, together with Bicyclo[1.1.1]pentane. Due to the presence of all sp3 carbons, Bicyclo[2.2.2]octanes can offer a number advantages over the traditional phenyl ring. The 3D structure can improve the binding site selectivity and efficiency, thus reducing toxicity and enhancing the potency of the drug. Furthermore, the lack of aromaticity could result in higher solubility. It is, however, important to keep into consideration the larger ring and increased lipophilicity of Bicyclo[2.2.2]octanes when planning to use these building blocks as phenyl isosteres.

As previously introduced, Bicyclo[2.2.2]octane is a 3D isosteres of the 2D phenyl ring, together with Bicyclo[1.1.1]pentane. Due to the presence of all sp3 carbons, Bicyclo[2.2.2]octanes can... read more »
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Bicyclo[2.2.2]octane

As previously introduced, Bicyclo[2.2.2]octane is a 3D isosteres of the 2D phenyl ring, together with Bicyclo[1.1.1]pentane. Due to the presence of all sp3 carbons, Bicyclo[2.2.2]octanes can offer a number advantages over the traditional phenyl ring. The 3D structure can improve the binding site selectivity and efficiency, thus reducing toxicity and enhancing the potency of the drug. Furthermore, the lack of aromaticity could result in higher solubility. It is, however, important to keep into consideration the larger ring and increased lipophilicity of Bicyclo[2.2.2]octanes when planning to use these building blocks as phenyl isosteres.

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AS58399-B-MG250 Ethyl...
Catalog # AS58399-B Formula: C11H20ClNO2 Mass: 233.74 C.A.S. / related C.A.S: [1626394-43-1] / [] MDL: MFCD30531327 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS97054-MG100 4-Bromobicyclo[2.2.2]octane-1-carboxylic acid 95+%
Catalog # AS97054 Formula: C9H13BrO2 Mass: 233.10 C.A.S. / related C.A.S: [1989-50-0] / [] MDL: MFCD00967720 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS96948-MG100 2-Oxabicyclo[2.2.2]octane-4-carbaldehyde 95+%
Catalog # AS96948 Formula: C8H12O2 Mass: 140.18 C.A.S. / related C.A.S: [1212021-23-2] / [] MDL: MFCD28402478 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS96963-MG100 Bicyclo[2.2.2]octane-1,4-diol 95+%
Catalog # AS96963 Formula: C8H14O2 Mass: 142.20 C.A.S. / related C.A.S: [1194-44-1] / [] MDL: MFCD00213487 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code: 29053995...
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AS56007-2S3S-G1 Methyl-(2S,3S)-3-aminobicyclo[2.2.2]octane-2-ca...
Catalog # AS56007-2S3S Formula: C10H18ClNO2 Mass: 219.71 C.A.S. / related C.A.S: [2173637-41-5] / [] MDL: MFCD31620811 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff...
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AS95741-MG100 Methyl 5-oxobicyclo[2.2.2]octane-2-carboxylate...
Catalog # AS95741 Formula: C10H14O3 Mass: 182.22 C.A.S. / related C.A.S: [78478-61-2] / [] MDL: MFCD29059279 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS95675-G1 3'H-4-Azaspiro[bicyclo[2.2.2]octane-2,2'-furo[2...
Catalog # AS95675 Formula: C13H17ClN2O Mass: 252.74 C.A.S. / related C.A.S: [2227204-89-7] / [] MDL: MFCD30802106 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS115502-MG100 Methyl...
Catalog # AS115502 Formula: C11H16O3 Mass: 196.24 C.A.S. / related C.A.S: [94994-25-9] / [] MDL: MFCD23102903 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS111306-MG100 Methyl...
Catalog # AS111306 Formula: C11H15NO2 Mass: 193.24 C.A.S. / related C.A.S: [54202-05-0] / [] MDL: MFCD23701712 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS95236-MG100 1-(Boc-amino)-4-hydroxybicyclo[2.2.2]octane 95%
Catalog # AS95236 Formula: C13H23NO3 Mass: 241.33 C.A.S. / related C.A.S: [1252672-84-6] / [] MDL: MFCD28403233 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS95205-MG100 Methyl bicyclo[2.2.2]octane-1-carboxylate 95%
Catalog # AS95205 Formula: C10H16O2 Mass: 168.23 C.A.S. / related C.A.S: [31818-12-9] / [] MDL: MFCD29042868 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS59844-MG100 (2S,3S)-3-Aminobicyclo[2.2.2]octane-2-carboxyli...
Catalog # AS59844 Formula: C9H15NO2 Mass: 169.22 C.A.S. / related C.A.S: [1621863-51-1] / [] MDL: MFCD30719355 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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