Bicyclo[1.1.1]pentane

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest diagonal distance, smallest size and lowest lipophilicity due to the low number of carbon atoms. All these properties make them the most useful isostere of the p-phenyl group, especially when a simple spacer without π-stacking properties is needed. In addition, Bicyclo[1.1.1]pentanes not only retain the biological activity of the parent compounds, but they also provide enhanced properties in terms of solubility, permeability, and in vitro stability. For these reasons, the importance of this class of building blocks is expected to grow in the near future.

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest... read more »
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Bicyclo[1.1.1]pentane

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest diagonal distance, smallest size and lowest lipophilicity due to the low number of carbon atoms. All these properties make them the most useful isostere of the p-phenyl group, especially when a simple spacer without π-stacking properties is needed. In addition, Bicyclo[1.1.1]pentanes not only retain the biological activity of the parent compounds, but they also provide enhanced properties in terms of solubility, permeability, and in vitro stability. For these reasons, the importance of this class of building blocks is expected to grow in the near future.

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AS55924-MG100 Methyl...
Catalog # AS55924 Formula: C12H19NO4 Mass: 241.28 C.A.S. / related C.A.S: [676371-64-5] / [] MDL: MFCD24476148 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: 0,96 pKa: Tariff Code:...
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AS55925-MG250 3-(Boc-amino)bicyclo[1.1.1]pentane-1-carboxylic...
Catalog # AS55925 Formula: C11H17NO4 Mass: 227.26 C.A.S. / related C.A.S: [303752-38-7] / [] MDL: MFCD09971715 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: 0,69 pKa: 4,456 Tariff...
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AS55926-MG250 Methyl...
Catalog # AS55926 Formula: C8H9NO2 Mass: 151.16 C.A.S. / related C.A.S: [156329-62-3] / [] MDL: MFCD27664945 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: 1,23 pKa: Tariff Code:...
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AS55927-MG100 N1,N3-dimethylbicyclo[1.1.1]pentane-1,3-diamine...
Catalog # AS55927 Formula: C7H16Cl2N2 Mass: 199.12 C.A.S. / related C.A.S: [1523572-06-6] / [] MDL: MFCD27987020 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: 7.578, 7.578...
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AS55928-MG100 1,3-Bis(Cbz-amino)bicyclo[1.1.1]pentane 95+%
Catalog # AS55928 Formula: C21H22N2O4 Mass: 366.41 C.A.S. / related C.A.S: [1566649-44-2] / [] MDL: MFCD27987021 Appearance: solid Colour: yellow Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: 2,5 pKa: Tariff...
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AS55808-B-MG100 Methyl...
Catalog # AS55808-B Formula: C7H12ClNO2 Mass: 177.63 C.A.S. / related C.A.S: [676371-65-6] / [] MDL: MFCD20720060 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: 9,031 Tariff...
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AS55766-MG250 Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid 95+%
Catalog # AS55766 Formula: C7H8O4 Mass: 156.14 C.A.S. / related C.A.S: [56842-95-6] / [] MDL: MFCD20621127 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: 0,49 pKa: 4.213, 4.213...
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AS55659-MG250 Dimethyl...
Catalog # AS55659 Formula: C9H12O4 Mass: 184.19 C.A.S. / related C.A.S: [115913-32-1] / [] MDL: MFCD23106317 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: 1,02 pKa: Tariff Code:...
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AS55665-MG250 1,1'-(Bicyclo[1.1.1]pentane-1,3-diyl)diethanone...
Catalog # AS55665 Formula: C9H12O2 Mass: 152.19 C.A.S. / related C.A.S: [115913-30-9] / [] MDL: MFCD23164149 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: 1,51 pKa: Tariff Code:...
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