Bicyclo[1.1.1]pentane

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest diagonal distance, smallest size and lowest lipophilicity due to the low number of carbon atoms. All these properties make them the most useful isostere of the p-phenyl group, especially when a simple spacer without π-stacking properties is needed. In addition, Bicyclo[1.1.1]pentanes not only retain the biological activity of the parent compounds, but they also provide enhanced properties in terms of solubility, permeability, and in vitro stability. For these reasons, the importance of this class of building blocks is expected to grow in the near future.

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest... read more »
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Bicyclo[1.1.1]pentane

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest diagonal distance, smallest size and lowest lipophilicity due to the low number of carbon atoms. All these properties make them the most useful isostere of the p-phenyl group, especially when a simple spacer without π-stacking properties is needed. In addition, Bicyclo[1.1.1]pentanes not only retain the biological activity of the parent compounds, but they also provide enhanced properties in terms of solubility, permeability, and in vitro stability. For these reasons, the importance of this class of building blocks is expected to grow in the near future.

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AS95544-MG100 1-(Boc-amino)-3-formylbicyclo[1.1.1]pentane 95+%
Catalog # AS95544 Formula: C11H17NO3 Mass: 211.26 C.A.S. / related C.A.S: [1638771-06-8] / [] MDL: MFCD27987008 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 338.00 € *
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AS95545-MG100 Methyl...
Catalog # AS95545 Formula: C13H21NO4 Mass: 255.31 C.A.S. / related C.A.S: [1638768-01-0] / [] MDL: MFCD27987010 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 325.00 € *
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AS95547-MG100 3-(Boc)-bicyclo[1.1.1]pentane-1-carboxylic acid...
Catalog # AS95547 Formula: C11H16O4 Mass: 212.24 C.A.S. / related C.A.S: [1638765-30-6] / [] MDL: MFCD27987015 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 393.00 € *
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AS95548-MG100 3-[2-(tert-butoxy)-2-oxoethyl]bicyclo[1.1.1]pen...
Catalog # AS95548 Formula: C12H18O4 Mass: 226.27 C.A.S. / related C.A.S: [1113001-76-5] / [] MDL: MFCD27987017 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 753.00 € *
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AS55808-A-MG100 Methyl...
Catalog # AS55808-A Formula: C7H11NO2 Mass: 141.17 C.A.S. / related C.A.S: [758684-88-7] / [] MDL: MFCD23164156 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS95359-MG100 1-(Cbz-amino)formylbicyclo[1.1.1]pentane 95%
Catalog # AS95359 Formula: C14H15NO3 Mass: 245.27 C.A.S. / related C.A.S: [2166952-44-7] / [] MDL: MFCD31620791 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS95363-MG100 3-Fluorobicyclo[1.1.1]pentane-1-carboxylic acid...
Catalog # AS95363 Formula: C6H7FO2 Mass: 130.12 C.A.S. / related C.A.S: [146038-53-1] / [] MDL: MFCD19228680 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS95376-MG250 3-Chlorobicyclo[1.1.1]pentane-1-carboxylic acid...
Catalog # AS95376 Formula: C6H7ClO2 Mass: 146.57 C.A.S. / related C.A.S: [156329-73-6] / [] MDL: MFCD19229248 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
2,040.00 € *
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AS95377-MG100 3-Phenylbicyclo[1.1.1]pentane-1-carboxylic acid...
Catalog # AS95377 Formula: C12H12O2 Mass: 188.22 C.A.S. / related C.A.S: [83249-04-1] / [] MDL: MFCD00101889 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
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AS95390-MG100 3-Aminobicyclo[1.1.1]pentane-1-carbonitrile 95%
Catalog # AS95390 Formula: C6H8N2 Mass: 108.14 C.A.S. / related C.A.S: [1936643-30-9] / [] MDL: MFCD30719357 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 324.00 € *
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AS95391-MG100 3-(Trifluoromethyl)bicyclo[1.1.1]pentane-1-carb...
Catalog # AS95391 Formula: C7H7F3O2 Mass: 180.12 C.A.S. / related C.A.S: [224584-18-3] / [] MDL: MFCD20544759 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 693.00 € *
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AS95394-MG250 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic...
Catalog # AS95394 Formula: C6H8O3 Mass: 128.13 C.A.S. / related C.A.S: [83249-08-5] / [] MDL: MFCD19230741 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 1,360.00 € *
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