Bicyclo[1.1.1]pentane

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest diagonal distance, smallest size and lowest lipophilicity due to the low number of carbon atoms. All these properties make them the most useful isostere of the p-phenyl group, especially when a simple spacer without π-stacking properties is needed. In addition, Bicyclo[1.1.1]pentanes not only retain the biological activity of the parent compounds, but they also provide enhanced properties in terms of solubility, permeability, and in vitro stability. For these reasons, the importance of this class of building blocks is expected to grow in the near future.

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest... read more »
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Bicyclo[1.1.1]pentane

As well as being a useful isostere of the p-phenyl group, Bicyclo[1.1.1]pentane, can also be employed as an isostere of the t-butyl group. In addition, they are characterized by the shortest diagonal distance, smallest size and lowest lipophilicity due to the low number of carbon atoms. All these properties make them the most useful isostere of the p-phenyl group, especially when a simple spacer without π-stacking properties is needed. In addition, Bicyclo[1.1.1]pentanes not only retain the biological activity of the parent compounds, but they also provide enhanced properties in terms of solubility, permeability, and in vitro stability. For these reasons, the importance of this class of building blocks is expected to grow in the near future.

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AS97124-G1 1,3-Diiodobicyclo[1.1.1]pentane 95+%
Catalog # AS97124 Formula: C5H6I2 Mass: 319.91 C.A.S. / related C.A.S: [105542-98-1] / [] MDL: MFCD29037325 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 858.00 € *
AS97051-MG100 3-(Aminomethyl)bicyclo[1.1.1]pentane-1-carbonit...
Catalog # AS97051 Formula: C7H10N2 Mass: 122.17 C.A.S. / related C.A.S: [1934858-95-3] / [] MDL: MFCD31696546 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 393.00 € *
AS97052-MG100 3-Phenylbicyclo[1.1.1]pentane-1-carbonitrile 95+%
Catalog # AS97052 Formula: C12H11N Mass: 169.22 C.A.S. / related C.A.S: [83249-01-8] / [] MDL: MFCD31666053 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 837.00 € *
AS96988-MG100 3-tert-Butylbicyclo[1.1.1]pentane-1-carboxylic...
Catalog # AS96988 Formula: C10H16O2 Mass: 168.23 C.A.S. / related C.A.S: [132663-73-1] / [] MDL: MFCD20639636 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 495.00 € *
AS96921-G1 3-Methoxybicyclo[1.1.1]pentane-1-carboxylic...
Catalog # AS96921 Formula: C7H10O3 Mass: 142.15 C.A.S. / related C.A.S: [156329-86-1] / [] MDL: MFCD30489919 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 595.00 € *
AS96651-MG100 1-Boc-3-aminobicyclo[1.1.1]pentane 95+%
Catalog # AS96651 Formula: C10H17NO2 Mass: 183.25 C.A.S. / related C.A.S: [1935523-60-6] / [] MDL: MFCD28389656 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 532.00 € *
AS96361-MG100 Methyl...
Catalog # AS96361 Formula: C7H10O3 Mass: 142.15 C.A.S. / related C.A.S: [2092825-26-6] / [] MDL: MFCD30802629 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 670.00 € *
AS96362-MG100 3-Cyanobicyclo[1.1.1]pentane-1-carboxylic acid...
Catalog # AS96362 Formula: C7H7NO2 Mass: 137.14 C.A.S. / related C.A.S: [83249-02-9] / [] MDL: MFCD19229172 Appearance: solid Colour: clear Hazardous Classification: Corrosive Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 344.00 € *
AS96363-G1 Bicyclo[1.1.1]pentane-1,3-diol 95+%
Catalog # AS96363 Formula: Mass: 100.05 C.A.S. / related C.A.S: [1312790-52-5] / [] MDL: MFCD30802631 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code: 29053995...
1,680.00 € *
AS96155-MG100 3-(Aminomethyl)bicyclo[1.1.1]pentane-1-carboxyl...
Catalog # AS96155 Formula: C7H12ClNO2 Mass: 177.63 C.A.S. / related C.A.S: [2173991-78-9] / [] MDL: MFCD31617921 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 562.00 € *
AS95884-MG100 3-Phenylbicyclo[1.1.1]pentane-1-carboxamide 95+%
Catalog # AS95884 Formula: C12H13NO Mass: 187.24 C.A.S. / related C.A.S: [2227206-18-8] / [] MDL: MFCD31696715 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 489.00 € *
AS95543-MG100 1-(Boc-amino)-3-(hydroxymethyl)bicyclo[1.1.1]pe...
Catalog # AS95543 Formula: C11H19NO3 Mass: 213.27 C.A.S. / related C.A.S: [1638765-26-0] / [] MDL: MFCD27987007 Appearance: solid Colour: clear Hazardous Classification: Warning Storage Temp: 2-7°C Refrigerate logP: pKa: Tariff Code:...
From 192.00 € *
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