Azabicyclo[3.1.0]hexane

Building on the pharmaceutical importance of Bicyclo[x.y.z]alkenes and exploiting the deep understanding of the synthetic methodologies to produce them, the next goal has been the extension of this class of compounds to include different 3D shapes. Bicyclo[3.1.0]octanes tend to be elongated versions of the [1.1.1] series, however the introduction of a bridge at a different length (as demonstrated in [3.1.1],[3.2.2],[2.1.1],[2.2.1] and [2.2.2] compounds) provides the possibility of 3-dimensional alternative to m-arenes. This is further demonstrated when one or more of the carbons is replaced by a nitrogen. For these reasons, a series of azabicyclo[3.1.0]hexane derivatives has been developed and added to our catalogue.